Tuesday, July 7, 2009

Rescue Protocols For Canine Lymphoma (Canine Lymphoma)

Canine Lymphoma

There are several CHOP-L protocols for Canine Lymphoma published for use, including the Wisconsin-Madison protocol, AMC protocol and VELCAP (Moore 2001). Although there are some differences among them in terms of scheduling, dosages and addition of other chemotherapeutics, the differences are minor and the protocols are considered to be equally effective.

Rescue Protocols Canine Lymphoma
When deciding on what protocol to use for initial treatment, it is important to take into account prognostic factors, including anatomic location, stage, grade, substage, immunophenotype and presence of hypercalcemia or a mediastinal mass. Most "average" dogs (Stage II-IVa B-cell intermediate to high-grade lymphoma) will benefit from a CHOP-L type of protocol.

It has not been documented whether dogs with negative prognostic factors (i.e., substage b) will have the same remission duration with a short-term protocol compared to "average" dogs with lymphoma. These dogs may be more effectively treated with protocols that include a maintenance phase. Those with T-cell lymphoma or certain anatomic locations (cutaneous or gastrointestinal) may benefit from the use of protocols such as MOPP as a first-line treatment.

The length of treatment with a rescue protocol is not standard. In our clinic, most rescue protocols are administered for no less than six months but no more than a year, providing that the patient continues to respond.

Canine Lymphoma

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