T-Cell Lymphoma in Dogs

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T-cell lymphoma in dogs, also known as canine lymphosarcoma, is a type of malignant cancer that attacks white blood cells known as T-cells. The disease usually begins in the lymph system or in the bone marrow, and it will eventually spread to the rest of the body if not treated.

Symptoms

Symptoms of T-cell lymphoma in dogs vary depending on which organ systems the cancer has spread to first. In most cases, the first sign of this disease is a swollen lymph node, which may grow to such an extent that the dog’s owner notices it through touch. T-cell lymphoma may also cause small tumors on the skin (normally around the chest or leg areas) or in the mouth. Additional symptoms of this disease include: loss of appetite, vomiting, lethargy, depression, fever, weakness, abdominal pain and weight loss.

Diagnosis

The most definitive diagnosis of canine lymphosarcoma is obtained through a microscopic examination of lymph tissue. The tissue is obtained through a biopsy, which is collected while the dog is sedated. Microscopic evaluation of the tissue will determine whether the dog’s symptoms are caused by canine lymphosarcoma or another type of condition (such as leukemia), and the evaluation will identify if the cancer is T-cell lymphosarcoma or B-cell lymphosarcoma.

Treatment

Chemotherapy treatments administered through intravenous routes are the most effective treatments for T-cell lymphoma in dogs. These treatments are given on a weekly basis for approximately 6 weeks and then reduced to every two weeks and then to every three weeks. Dogs tolerate chemotherapy very well and usually do not experience the side effects that are associated with chemotherapy treatments in people.

Prognosis

Canine T-cell lymphoma has a poorer prognosis than B-cell lymphoma cases, but with both of these cancers, dogs do not usually live longer than two years after their diagnosis. Dogs with T-cell lymphoma tend to have less of a response to chemotherapy treatments and a shorter remission period. However, if the disease is caught in the early stages, a dog’s chances of extended survival are much better; for this reason, it is important to see your veterinarian immediately if you notice any unusual lumps on your dog or additional symptoms associated with this disease.

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New Joint Venture Launches Canine Lymphoma Test

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A new canine lymphoma diagnostic kit can differentiate patients with lymphadenopathy due to lymphoma from ones with lymphadenopathy due to other ailments, such as lymphoid hyperplasia.

The Tri-Screen Canine Lymphoma Assay Kit is the first product to be offered by Tri-Screen—a new joint venture between Ireland-based animal diagnostic technology firm Tridelta Development Ltd. and animal cancer test developer Petscreen Ltd. of the U.K.

Petscreen developed the Advanced Lymphoma Blood Test on which the kit is based. The test combines relative values of the acute phase proteins haptoglobin and C-reactive protein in a patient’s blood serum into an analytical algorithm to determine if a patient’s lymphadenopathy is due to lymphoma or another ailment.

Canine Lymphoma Test

Petscreen enlisted support from veterinarians in the U.S. and the U.K. to test the method on samples from 194 canine patients with lymphoma, diseases with similar presentation to lymphoma, and healthy dogs.

Petscreen said it partnered with Tridelta because of the company’s reputation and experience with the international pharmaceutical industry in the niche sector of manufacturing and marketing acute phase protein diagnostic kits.

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Dealing with Canine Lymphoma

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Chemotherapy is extremely efficient in treating canine lymphoma. Most efficient are multi-agent chemotherapy regimens that utilize a mixture of drugs. There have been much more accomplishment with this program than with therapy utilizing only just one drug.

Eighty % of canines that obtain multi-agent chemotherapy regimens go right into a year-long remission. although it is feasible for them to expertise a 2nd remission, it is normally not as prolonged since the primary one. As some from the cancer tissue will produce a resistance towards the primary circular of prescription drugs used, there are heading to be a have to discover the proper program of prescription drugs for that 2nd remission to work. this can be accomplished by easy trial and error. It ought to be noted that even although the multi-agent program raises the dog’s existence span, they are much more high-priced and toxic than solo medicine regimens.

How profitable the chemotherapy therapy is is dependent upon exactly where the tumor is located, what phase the cancer is in, and how wholesome the puppy is once the cancer is diagnosed. Lymphoma from the bone marrow or even the thymus lower probabilities for any remission. canines that aren’t exhibiting any indications that include diarrhea and vomiting and appear to really feel properly in the preliminary diagnosis appear to respond far better to chemotherapy. part outcomes of chemotherapy in canines are typically minimal and mild. These might consist of deprivation of appetite, diarrhea, vomiting and lower blood vessels mobile count.

Prednisone, a sort of corticosteroid, can offer as very much as two to three weeks remission. This technique is utilized once the puppy is not a superb applicant for chemotherapy or even the proprietor cannot afford the cost of it. This essentially tends to make the dog’s remaining time much more comfortable.

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When The Diagnosis is Canine Cancer … (Canine Lymphoma)

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Canine lymphoma is the most common form of cancer in dogs. It can initally be limited to one organ or can spread throughout the body. Many parts of the body contain lymphatic tissue, and the disease can appear in different forms.

The most common target organs are primarily the lymph nodes, followed by the liver and spleen. The disease can also affect the gastrointestinal tract and, rarely, the eyes or skin.

Middle-aged dogs are most at risk, often after the age of 7 or 8.

Some breeds are more commonly affected, with the golden retriever, pit bull, Rottweiler, beagle and boxer often victims of lymphoma. In the golden retriever, there appears to be a specific inheritance pattern, although it is not yet completely clear.

In the common form, a dog has a poor appetite, feels “off,” and often has swellings that feel large and firm, especially in the neck, hind legs, groin and under the arms. These are large lymph nodes, and the doctor will usually take samples of these to send to the laboratory. In the gastrointestinal form, the patient can present with diarrhea, vomiting, weight loss or loss of appetite.

This disease is often very quick to spread and cause organ failure. The typical course from diagnosis to severe illness and death is often measured in months. In years past, we were unable to offer much more than cortisone tablets in an effort to make the patient comfortable for a short period of time. With the advent of chemotherapy, many owners choose to consult with a cancer specialist, or veterinary oncologist, to discuss options. Chemotherapy can be very effective at putting the disease into remission, sometimes for a long period of time, often without severe side effects.

If you should ever suspect that your dog might be affected by this disease, be sure to consult with your veterinarian. Often there is much we can do to be of help to you and your pet.

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A New Treatment for Canine Lymphoma? (Canine Lymphoma)

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Canine Lymphoma

Researchers at the University of Illinois are testing a new lymphoma treatment for dogs. This new drug acts on a specific enzyme called procaspase-3 that causes cancer cells to die. Many cancers in humans and animals contain high levels of procaspase-3, which means this drug could be a target for cancers in both animals and humans.

While testing this new compound, called PAC-1, in dogs, researchers discovered it made their brain cells more excitable by binding to zinc. To offset this undesirable effect, they modified PAC-1 so that this is no longer a problem. This new lymphoma treatment for seems to have few risks or side effects.

Unfortunately, this treatment for dog lymphoma needs further testing and may not be approved by the FDA for several years. In the meantime, chemotherapy, using already approved cancer drugs, remains the standard treatment approach. Not all dogs respond to chemotherapy for canine lymphoma – especially if the diagnosis is made too late.

Canine Lymphoma

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Homeopathic Remedies For Canine Lymphoma

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Canine Lymphoma

Although the primary treatment for Canine Lymphoma is chemotherapy, natural remedies can be quite beneficial and are recommended to help boost your dog's immune system.

Herbs
EchinaceaRed clover, burdock root, milk thistle, dandelion, astragalus and echinacea are immune boosting herbs, and many of them promote the removal of wastes from the kidneys and liver, which increases immune function and keeps your dog healthy while undergoing more conventional treatments like chemotherapy. These herbs should be dried and given orally to your dog.

Diet

Diet is another important factor in aiding your dog's battle with Lymphoma. Dogs diagnosed with Lymphoma should eat an organic raw diet or a specific cancer diet that consists of low carbohydrates and high fat intake. A small intake of complex carbohydrates and rapidly absorbed sugars along with moderate amounts of high quality proteins and high intake of unsaturated fats is recommended. The unsaturated fats should be Omega-3 fatty acids like those contained in flax seed oil and not Omega-6 fatty acids, which increase cancer growth. The only risk associated with the high fat diet is pancreatitis, which can develop in some breeds. Monitor your dog for any problems or ask your veterinarian beforehand if she knows whether your dog is susceptible to pancreatitis.

Canine Lymphoma

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Prednisone For Canine Cancer (Canine Lymphoma)

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Canine Lymphoma

Dogs develop some cancers at very high rates, according to the College of Veterinary Medicine at Texas A&M. Although sometimes used for other types of cancer, lymphoma and mast cell tumors are the cancers most likely to include prednisone as part of treatment.

Prednisone
Prednisone is part of glucocorticoids class of hormones. It is used for its anti-inflammatory ability, according to Wendy C. Brooks, D.V.M.

Side Effects
Prednisone side effects include excessive thirst and urination, latent bladder infection, gastro-intestinal problems and increased blood sugar levels and appetite. If prednisone is stopped abruptly, it can cause problems related to shutting off of your dog's natural corticosteroid production, according to Brooks.

Lymphoma
Lymphoma is a malignant cancer resulting in tumors that grow in your dog's organs. Prednisone use for lymphoma is usually in conjunction with chemotherapy drugs depending on the protocol used, according to Vetinfo. Prednisone may be used alone to control symptoms and short-term remission.

MCTs
Mast cell tumors is cancer that affects the mast cells. The tumors cause the cells to release chemicals that damage the body, according to the Canine Cancer Website. Surgery to remove the tumor is preferred. Prednisone is the preferred treatment for high-grade tumors, with or without chemotherapy.

Purpose
Prednisone does not cure cancer. It may help your dog go into remission, decrease cancer symptoms and improve chemotherapy drug response.

Warning
Do not use with non-steroidal anti-inflammatory drugs to avoid gastro-intestinal bleeding.

Source: eHow.com

Canine Lymphoma

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Bone Marrow Transplant Now Offered as a Cure for Canine Lymphoma at the Veterinary Specialty Center of the Hudson Valley

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Canine Lymphoma
Wappingers Falls, New York (PRWEB) April 24, 2010

The Veterinary Specialty Center of the Hudson Valley (VSCHV) announces Bone Marrow Transplant (BMT) as treatment for Canine Lymphosarcoma (Lymphoma). VSCHV is one of only 5 centers in the world, and the only facility in the north-eastern region of the United States where Bone Marrow Transplants are offered for your pet.

Lymphoma is a type of cancer of the white blood cells. The Bone Marrow Transplant procedure requires that the patient be put into molecular remission. At that time, cancer-free stem cells are removed from the patient. Radiation therapy is then used to eradicate any remaining cancer cells anywhere else in the body. The patient is supported in a state-of-the-art ICU facility during which the stem cells are placed back into the patient to re-grow the bone marrow and the immune system-- without the cancer cells. A successful treatment allows the patient to live a cancer-free life.

“Our dog was just too important to us; we had to try everything,” said Bob Akmens owner of Flopsy, an 11-year-old German Short-Haired Pointer, suffering from lymphoma. “He is part of our family and the BMT procedure gave us hope that otherwise would be impossible. I am so happy we found Dr. Impellizeri so we could give Flopsy a real chance at being cured.”

“Lymphoma is one of the most common cancers we see. A bone marrow transplant can be an actual 'cure for cancer' in 50-75% of the cases,” announced Dr. Joseph Impellizeri, DVM, Diplomate ACVIM (Oncology)-Medical Director. “As a veterinary oncologist, the chance to offer a cure for an otherwise fatal cancer is a dream come true.”

About the Veterinary Specialty Center of the Hudson Valley

The Veterinary Specialty Center of the Hudson Valley is a comprehensive multi-specialty practice with 24-7 emergency and critical care and services from board-certified specialists in Internal Medicine, Surgery, Oncology, Cardiology and Radiology. VSCHV has the most advanced imaging center in the Hudson Valley region with a 1.5T MRI, Computed Tomography, Digital Radiography, Ultrasound, Arthroscopy and Endoscopy. VSCHV is a leader in cancer therapies and offers a host of progressive treatments and minimally invasive procedures that give pet owners peace, comfort and hope. www.vschv.com # # #

Source : www.prweb.com

Canine Lymphoma

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Soy May Aid In Treating Canine Cancers (Canine Lymphoma)

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Canine Lymphoma

Researchers at North Carolina State University are looking to soy as a way to make traditional canine cancer therapy more effective, less stressful for the dog and less costly for the owners.

Dr. Steven Suter, assistant professor of oncology, and NC State colleagues studied genistein - a molecule found in soy that has been shown to be toxic to a wide variety of cancer cells in humans - to determine whether it would also inhibit the growth of canine lymphoma cells.

The researchers found that a commercially available form of genistein called GCP was effective in killing canine lymphoid cells in a laboratory setting, and that GCP is "bioavailable" in canines - meaning it is absorbed into the bloodstream where it can affect cancer cells in the body. The researchers hope that their findings will lead to the use of GCP for their canine patients in conjunction with traditional cancer treatments like chemotherapy.

The researchers' findings were published in Clinical Cancer Research.

"Humans have been using soy in conjunction with traditional chemotherapy for some time as a chemo potentiator," Suter says. "This means that the GCP makes the chemotherapy work more efficiently and faster, which translates to less stress on the patient and less money spent on chemotherapy."

Since dogs absorb GCP in much the same way that humans do, Suter hopes that veterinarians will be able to offer this therapy to canine patients in the near future.

"Since GCP is a dietary supplement, it is harmless to patients," he adds. "Plus it's inexpensive and easy to administer in a pill form. There's really no downside here."

Source: www.sciencedaily.com

Canine Lymphoma

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Scientific Breakthrough In The Screening & Treatment Of Canine Lymphoma Cancer Is A World First

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Canine Lymphoma

Canine lymphoma is one of the most prolific cancers in the dog population. It accounts for more than 20 percent of all cancers and in certain high risk breeds this figure could be considerably higher. Now a pioneering British bioscience company, PetScreen Limited (http://www.pet-screen.com) has announced an innovative screening and treatment optimisation programme which is the first of its kind to be made commercially available.

The screen is inexpensive, minimally invasive and relies on a small blood sample which can be taken by any vet, and then conveniently shipped directly to PetScreen's laboratories in Nottingham from anywhere in the world using a global logistics partnership with FedEx.

PetScreen has developed the screen based on proteomic technology which has emerged from the sequencing of both the human and canine genomes. It facilitates regular, routine screening which enables cancer to be detected at a much earlier stage when, as in humans, treatment has the best chance of success. The problems associated with the late detection of cancer are well understood, and whilst proteomic screening is at a comparatively early stage in humans, an ovarian cancer screen is expected to be announced in the United States next year... the work that PetScreen is undertaking in the canine world will have a significant impact for both four and two legs.

The scientific team, led by Dr Shahid Mian, has uniquely developed advanced biomarker technology for companion animals, specifically canine at the moment, but a feline lymphoma screen is planned for next year. Additional cancer screens for other major canine tumours will also be announced in 2007.

By looking for a "protein fingerprint" in the blood sample, the PetScreen proteomic screen enables very accurate and sensitive detection of the tumour, but just as importantly, indicates that the dog is free of lymphoma. The screen should therefore be regarded as part of an overall wellness programme for all breeds and provides owners with peace of mind ... particularly high risk breeds, which include both golden and flat-coated retrievers, boxers, rottweilers, German shepherds, spaniels and many breeds of mountain dogs. Ideally a mature pup should be screened at twelve months and then annually. For high risk breeds and dogs from middle age onwards, bi-annual screening should be considered, since six months in the life of a dog is equivalent to approximately three years in human terms. Any dog which may have been treated for lymphoma should be screened bi-annually to monitor for recurrence.

One in four dogs will develop cancer in their lifetime. Therefore, to complement the screening technology, PetScreen has developed a novel treatment optimisation programme which helps vets select the most appropriate chemotherapy treatment for each patient.

PetScreen recognise the impact of this devastating disease on dogs and owners alike. The company was co-founded by business partners who share a passion for dogs. The company's Chairman Professor Graeme Radcliffe, had lost three young dogs to cancer over a five year period. His determination to do something positive led to a chance meeting with Chief Executive, Dr Kevin Slater, an entrepreneurial bioscientist who had worked on human biomarker programmes. The meeting led to the partnership which founded Petscreen ... and the development of this innovative screening and treatment programme.

Source: www.medicalnewstoday.com

Canine Lymphoma

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Does Your Dog Have Canine Lymphoma? (Canine Lymphoma)

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Canine Lymphoma

Dogs are touted as being man's best friend, and you will be hard-pressed to find a more loyal and lovable animal to call your pet than a dog. With this love and loyalty, there are a few things that you have to do to show your dog how much you care about them as well. Feeding, watering, and taking out for walks are but a few things that you need to do to show your dog this love and companionship. Another thing is making sure they are healthy by taking them to the vet.

One thing that a dog owner never wants to hear is that their dog is suffering from canine lymphoma. This cancer was first reported in the 1980's and was initially thought to affect only a certain amount of cross bred canines. While most cases have been attributed to the genetic mistakes in some breeds, just about any dog can contract canine lymphoma, and making sure they stay healthy is the best thing you can do to prevent this from happening. The life expectancy of a dog with lymphoma is between 9 and 12 months.

While the life expectancy isn't that great, there are ways that you can put the cancer into remission and your dog can then enjoy many more years of life. Using a combination of chemotherapy, immune boosting, and radiation with a healthy high protein diet can help boost your dog's ability to have its cancer go into remission. While making these changes are still fairly difficult on your dog, if the cancer does go into remission you will both feel much better about making these changes. Remission for canine lymphoma is fairly high, so taking steps as soon as possible will help you the most.

If you start to notice that your dog is losing its appetite, vomiting, and is getting lumps on its abdomen neck or armpits, you should take it to the vet as soon as possible. These are the places that lymphoma is going to hit first, and if you don't take action the cancerous tumors will start to spread through its vital organs. Once they hit the vital organs, there is only a few months left before your dog will go through organ failure and pass away. Take the time to visit your vet every year and have tests performed to see if your dog might have, or could contract canine lymphoma.

Source: ezinearticles.com by Anne Ming

Canine Lymphoma

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